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The Expression of 5-lipoxygenase and the Activation and Cytotoxicity of 4-Aminobiphenyl in Human Bron
[Objectives] The effects of 4-aminobiphenyl to 5-lipoxygenase protein expression and cytotoxicity and DNA damage were been investigated in HBE cells, with the experiment that can affirm the co-oxidation of 4-aminobiphenyl mediated by SLO in....
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Mitochondrial Damage Induced by Hexavalent Chromium under the Condition of p53 Closed in L-02 Hepatoc
Objective:To explore the mitochondria damage induced by hexavalent chromium(Cr(Ⅵ)under the condition of p53 closed in L-02 hepatocytes,and to further investigate the pathway of apoptosis induced independently by mitochondria damage in L-02....
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Study on Ecotoxicological Indicators of Fish Intoxicated by Roxarsone
In order to provide a reference that the influence of Roxarsone on Na~+-K~+-ATPase in crap's tissue and DNA damage. Firstly, liver, kidney and gill were collected from craps at 48, 96, and 144 hours from Roxarsone exposure group in which cra....
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The DNA Damage Induced by Roxarsone in Chinese Hamster Lung Cells by the Single-cell Gel Electrophore
Roxarsone, a organoarsenic additive, with antibiotic effect, growth promotion and improving feed efficiency, was widely used in livestock and animal production. The residues of organoarsenic compound in animal manure were run into environmen....
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Differential Expression of Ubiquitin C-Terminal Hydrolase L-1 in Testes Following Exposure to Di(nbut
Objective:To identify and analyze differential expression of UCHL1 in rat offspring testes after maternal exposure to di(nbutyl)phthalate (DBP).Methods:Forty pregnant rats were randomly divided into two groups and were given DBP by gastric i....
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The Roles of JNK Signaling Pathway in Dimethylarsinic Acid-Induced DNA Damage and Apoptosis in Human
Arsenic is a known carcinogeon in human. Arsenic intoxication occurs in many areas through the consumption of contaminated well water or foods containing inorganic arsenicals. On the other hand, inorganic arsenite has emerged as an outstandi....
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Study on the Apoptosis and Mechanism of Manganese Chloride-induced PC12 Cells
ObjectiveBy using PC12 cells as the model of dopaminergic neuron, this article observed the cell growth, proliferation and apoptosis of PC12 cells,detected the expression and location of Hsp70、Survivin、Bcl-2 and Bax proteins in PC12 cell....